Exploring Nutrition and Supplements for Autism

Overview: This article explores the research on specific diets and supplements and their use in managing autism symptoms. 


The adage you are what you eat is a metaphorical expression that implies that our health and well-being are impacted by diet. This notion is scientifically proven for all people, but it especially holds for autistic individuals who are susceptible to dietary alterations due to genetic variations that can impact the intake, transport, and accumulation of vitamins and minerals in their bodies (Adams et al. 2011). These small changes can have a big impact on brain and body development, making the monitoring of food intake an essential part of care and treatment of potential symptoms. 

As with all diet and supplement information available on the web, it is important to look to well-researched, double-blind studies to truly determine the impact of specific dietary approaches for managing autism. A quick scroll through social media is likely to show someone extolling the unique virtues of red meat consumption right next to someone explaining the deadly consequences of eating that same meat. Given that cacophony, for purposes of this article I relied solely on high quality research to discern the most reliable current scientific data without providing specific recommendations. The goal here is to provide reliable data that allows you to make the best decisions for you and your family. 

Diets and Autism

New diets “pop” into pop-culture daily, but many if not most of them are not tested for their benefits for specific populations. Luckily, there has been a good amount of research into the impact of certain diets on autistic individuals. Much of the research focuses on the varying impact of fat, protein, carbohydrates, gluten, and dairy. As with any significant health decision, it is recommended that any dietary decisions are made with the assistance of a physician and/or dietician to ensure that all nutrition standards are met. Four major takeaways from this research are as follows:

  1. Keto Diet

    • A high-fat, low-protein and low-carbohydrate diet that is usually followed for multiple years. 

    • Shown to benefit the following symptoms for autistic people (Li et al, 2021; Cheng et al, 2017)

      • Behavioral improvements with less required energy

      • Better attention span, communication skills, and emotion regulation

      • Shifts in gene expression that may lessen challenging ASD symptoms

  2. Gluten Free Diet

    • A diet that excludes gluten, which is a protein commonly found in wheat, barley, and rye. 

    • Shown to benefit cognitive skills and behavioral regulation symptoms for autistic people (Catassi et al. 2013).

    • There is no health risk in trying a gluten-free diet. 

    • A gluten-free diet is sometimes combined with a casein-free diet. 

  3. Gluten Free - Casein Free Diet

    • A diet that excludes gluten as well as casein, which is a protein commonly found in animal milk and milk products. 

    • Research shows a varying impact on autism symptoms which suggests that more research is necessary (González-Domenech et al. 2020). However, there is no health risk in trying this diet if the rest of one’s diet is well balanced. 

    • It is recommended that people who go casein free supplement their diet with calcium to avoid any potential dietary deficiencies. 

  4. Avoiding Artificial Food Dyes

    • A diet that excludes food dyes such as Blue 1 and 2, Green 3, Red 3, Yellow 5 and 6, Citrus Red 2, and Red 40.

    • Research suggests that consuming these colors can exacerbate autism symptoms, sleep issues, and attention deficit hyperactivity symptoms (Bakthavachalu, et al, 2020). 

Vitamins and Minerals

Food supplements are also often touted as a universal panacea.  The challenging issue with determining the benefits of vitamins and minerals is that every person has a different metabolism, diet, and genetic phenotype. This makes establishing a “one size fits all” vitamin and mineral regiment impossible for all autistic individuals. I am not a medical doctor and cannot provide medical advice on this matter. I can tell you, however, that there are studies, such as Adams et al. (2011) that suggest that a comprehensive vitamin/mineral supplement can reduce hyperactivity, emotional breakdowns, and problems with receptive language in autistic people. The medical criticism of this position, and other similar studies, is that it is difficult to control for the differences in individual diet, metabolism, genetics, and environmental factors. 

If you or your family member would like to try to replicate some of these benefits using a multivitamin, it is recommended that you use a product that minimizes unnecessary dyes and sugars – the Clean Lebel Project (cleanlabelproject.org) does a good job of certifying such things. You may also want to explore 3rd Party tests that certify the ingredients in the vitamin from organizations like NSF International and US Pharmacopeia. Finally, when feasible it is best to seek out multivitamins that are from “whole foods.” Not the grocery store, but rather vitamins that are derived from actual food instead of being synthesized in a lab. 

I recognize that the most likely approach is to try different products until one of them “feels” right, but there are individuals who want to know the exact impact of each individual vitamin or mineral. For those of you, I have included the below chart that summarizes the impact of each supplement on ASD symptoms.  Note that this chart/article is merely an introduction to the research on food supplements and should not be the sole criteria for your decisions.  As with any medical intervention, it is best to consult with your doctor about the best course of action for you or your family member. 

Resources

Adams, J.B., Audhya, T., McDonough-Means, S. et al. (2011). Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr 11, 111. 


Adams, J. B., Audhya, T., Geis, E., Gehn, E., Fimbres, V., Pollard, E. L., ... & Quig, D. W. (2018). Comprehensive nutritional and dietary intervention for autism spectrum disorder—a randomized, controlled 12-month trial. Nutrients10(3), 369.


Bakthavachalu, P., Kannan, S. M., & Qoronfleh, M. W. (2020). Food color and autism: a meta-analysis. Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management, 481-504.


Benke, P. J., Duchowny, M., & McKnight, D. (2018). Biotin and acetazolamide for treatment of an unusual child with autism plus lack of nail and hair growth. Pediatric neurology79, 61-64.


Catassi C, Bai JC, Bonaz B, Bouma G, Calabrò A, Carroccio A, Castillejo G, Ciacci C, Cristofori F, Dolinsek J, et al. (2013). Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders. Nutrients


Cheng N, Rho JM, Masino SA. (2017). Metabolic dysfunction underlying autism spectrum disorder and potential treatment approaches. Front Mol Neuroscience. 10:34.


Christensen DL, Maenner MJ, Bilder D, et al. (2019). Prevalence and characteristics of autism spectrum disorder among children aged 4 years — Early Autism and Developmental Disabilities Monitoring Network, seven sites, United States, 2010, 2012, and 2014. MMWR CDC Surveill Summ. 68:1-19.


Criado KK, Sharp WG, McCracken CE, et al. (2018). Overweight and obese status in children with autism spectrum disorder and disruptive behavior. Autism. 2018, 22:450-459.


Curtin C, Must A, Phillips S, Bandini L. (2017). The healthy weight research network: a research agenda to promote healthy weight among youth with autism spectrum disorder and other developmental disabilities. Pediatr Obes. 12:e6-e9.


Doreswamy, S., Bashir, A., Guarecuco, J. E., Lahori, S., Baig, A., Narra, L. R., ... & Heindl, S. E. (2020). Effects of diet, nutrition, and exercise in children with autism and autism spectrum disorder: A literature review. Cureus12(12).


Egan AM, Dreyer ML, Odar CC, Beckwith M, Garrison CB. (2013). Obesity in young children with autism spectrum disorders: prevalence and associated factors. Child Obes. 9:125-131.


González-Domenech, P. J., Díaz Atienza, F., García Pablos, C., Fernández Soto, M. L., Martínez-Ortega, J. M., & Gutiérrez-Rojas, L. (2020). Influence of a combined gluten-free and casein-free diet on behavior disorders in children and adolescents diagnosed with autism spectrum disorder: a 12-month follow-up clinical trial. Journal of autism and developmental disorders50, 935-948.


Guo, M., Zhu, J., Yang, T., Lai, X., Liu, X., Liu, J., ... & Li, T. (2018). Vitamin A improves the symptoms of autism spectrum disorders and decreases 5-hydroxytryptamine (5-HT): a pilot study. Brain Research Bulletin137, 35-40.


Hagmeyer, S., Sauer, A. K., & Grabrucker, A. M. (2018). Prospects of zinc supplementation in autism spectrum disorders and Shankopathies such as Phelan McDermid Syndrome. Frontiers in synaptic neuroscience10, 11.


Hill AP, Zuckerman KE, Fombonne E. (2015). Obesity and autism. Pediatrics. 136:1051-1061


Indika, Neluwa-Liyanage R., Richard E. Frye, Daniel A. Rossignol, Susan C. Owens, Udara D. Senarathne, Andreas M. Grabrucker, Rasika Perera, Marielle P. K. J. Engelen, and Nicolaas E. P. Deutz. 2023. "The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder" Journal of Personalized Medicine 13, no. 2: 252. https://doi.org/10.3390/jpm13020252


McWilliams, S., Singh, I., Leung, W., Stockler, S., & Ipsiroglu, O. S. (2022). Iron deficiency and common neurodevelopmental disorders—A scoping review. PLoS One17(9), e0273819.


Morris, C. R., & Agin, M. C. (2009). Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation. Alternative Therapies in Health & Medicine15(4), 34.


Navarro F, Liu Y, Rhoads JM. (2016). Can probiotics benefit children with autism spectrum disorders? World J Gastroenterol. Dec 14;22(46):10093-10102. 


Li Q, Liang J, Fu N, Han Y, Qin J. A. (2021). Ketogenic Diet and the Treatment of Autism Spectrum Disorder. Front Pediatr. May 11;9:650624.


Li, B., Xu, Y., Zhang, X., Zhang, L., Wu, Y., Wang, X., & Zhu, C. (2022). The effect of vitamin D supplementation in treatment of children with autism spectrum disorder: a systematic review and meta-analysis of randomized controlled trials. Nutritional neuroscience25(4), 835-845.


Nadon G, Feldman DE, Dunn W, Gisel E/ (2011). Association of sensory processing and eating problems in children with autism spectrum disorders. Autism Res Treat. 2011, 2011:541926


Niyazov, D. M., Kahler, S. G., & Frye, R. E. (2016). Primary mitochondrial disease and secondary mitochondrial dysfunction: importance of distinction for diagnosis and treatment. Molecular syndromology7(3), 122-137.


Rossignol, D. A., & Frye, R. E. (2021a). Cerebral folate deficiency, folate receptor alpha autoantibodies and leucovorin (folinic acid) treatment in autism spectrum disorders: a systematic review and meta-analysis. Journal of personalized medicine11(11), 1141.


Rossignol, D. A., & Frye, R. E. (2021). The effectiveness of cobalamin (B12) treatment for autism spectrum disorder: a systematic review and meta-analysis. Journal of personalized medicine11(8), 784.


Żarnowska I, Chrapko B, Gwizda G, Nocuń A, Mitosek-Szewczyk K, Gasior M. (2018). Therapeutic use of carbohydrate-restricted diets in an autistic child; a case report of clinical and 18FDG PET findings. Metab Brain Dis.,33:1187-1192



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